Mary Jeanne Kreek Selected Research

Heroin Dependence (Heroin Abuse)

1/2021	Polymorphisms in Stress-Related Genes Are Associated with Reduced Cocaine Abuse and Longer Retention in Methadone Maintenance Treatment for Opioid Use Disorder.
1/2018	Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: Gender-specific features.
1/2018	A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction.
1/2018	Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.
11/2016	Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence.
1/2016	Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry.
1/2016	African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.
11/2015	Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.
5/2015	Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.
7/2014	Drug addiction and stress-response genetic variability: association study in African Americans.

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Mary Jeanne Kreek Research Topics

Disease

40	Opioid-Related Disorders (Opiate Addiction) 03/2022 - 01/2002
36	Cocaine-Related Disorders (Cocaine Addiction) 02/2022 - 05/2002
23	Alcoholism (Alcohol Abuse) 01/2022 - 02/2002
21	Heroin Dependence (Heroin Abuse) 01/2021 - 02/2003
20	Substance-Related Disorders (Drug Abuse) 01/2022 - 08/2004
9	Anhedonia 01/2022 - 01/2015
6	Pain (Aches) 01/2022 - 09/2003
4	Infections 03/2015 - 01/2002
4	Hepatitis C 09/2013 - 01/2002
3	Brain Diseases (Brain Disorder) 04/2020 - 02/2010
3	Tobacco Use Disorder (Nicotine Dependence) 03/2016 - 03/2003
2	Ataxia (Dyssynergia) 01/2022 - 01/2018
2	Liver Diseases (Liver Disease) 01/2022 - 02/2009
2	Chronic Pain 09/2021 - 07/2010
2	AIDS-Related Complex (ARC) 01/2019 - 06/2003
2	Mental Disorders (Mental Disorder) 01/2018 - 01/2006
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2018 - 04/2009
2	Inflammation (Inflammations) 08/2017 - 01/2014
2	Genetic Predisposition to Disease (Genetic Predisposition) 05/2015 - 01/2015
2	Shock 02/2015 - 01/2008
2	Cognitive Dysfunction 03/2013 - 10/2011
2	Hepatitis 09/2010 - 04/2008
2	Hepatitis A (Hepatitis, Infectious) 02/2009 - 04/2008
2	Hepatitis B 02/2009 - 04/2008
2	Coinfection 04/2008 - 01/2002
2	Hyperalgesia 10/2004 - 09/2003
1	Mood Disorders (Mood Disorder) 01/2022
1	Opiate Overdose 09/2021
1	Respiratory Insufficiency (Respiratory Failure) 09/2021
1	Obesity 01/2019
1	Marijuana Abuse (Cannabis Abuse) 01/2018

Drug/Important Bio-Agent (IBA)

27	Cocaine (Cocaine HCl)IBA 02/2022 - 10/2002
25	Opioid Analgesics (Opioids)IBA 02/2022 - 06/2002
24	Heroin (Diamorphine)IBA 02/2022 - 01/2002
24	Pharmaceutical PreparationsIBA 01/2022 - 05/2003
24	Methadone (Dolophine)FDA LinkGeneric 01/2021 - 01/2002
11	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2022 - 12/2004
11	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2021 - 02/2005
11	Opiate AlkaloidsIBA 03/2013 - 01/2002
10	Naltrexone (ReVia)FDA LinkGeneric 11/2020 - 02/2002
7	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 01/2021 - 01/2002
5	preproenkephalinIBA 11/2020 - 05/2002
4	Narcotic Antagonists (Opioid Antagonists)IBA 09/2021 - 02/2002
4	Dynorphins (Dynorphin)IBA 05/2021 - 08/2003
4	Opioid Receptors (Opioid Receptor)IBA 01/2019 - 02/2003
3	LigandsIBA 01/2022 - 03/2013
3	TRK 820IBA 01/2022 - 01/2019
3	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 04/2008
3	Buprenorphine (Subutex)FDA LinkGeneric 11/2020 - 02/2003
3	Oxycodone (Oxycontin)FDA LinkGeneric 01/2019 - 08/2017
3	salvinorin AIBA 01/2019 - 01/2015
3	RNA (Ribonucleic Acid)IBA 11/2018 - 04/2008
3	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 12/2005
3	Morphine (MS Contin)FDA LinkGeneric 06/2012 - 03/2005
2	Naloxone (Narcan)FDA LinkGeneric 09/2021 - 11/2020
2	Fentanyl (Sublimaze)FDA LinkGeneric 09/2021 - 10/2004
2	Carrier Proteins (Binding Protein)IBA 01/2021 - 11/2019
2	nalmefene (Revex)FDA Link 01/2020 - 12/2005
2	Adrenocorticotropic Hormone (ACTH)FDA Link 11/2019 - 04/2009
2	Hormones (Hormone)IBA 11/2019 - 01/2018
2	3' Untranslated Regions (3' UTR)IBA 01/2019 - 04/2009
2	Long Noncoding RNAIBA 01/2019 - 01/2018
2	ProlactinIBA 01/2018 - 08/2003
2	AticaprantIBA 01/2018 - 01/2018
2	1- (5- chloro- 1- ((2,4- dimethoxyphenyl)sulfonyl)- 3- (2- methoxyphenyl)- 2- oxo- 2,3- dihydro- 1H- indol- 3- yl)- 4- hydroxy- N,N- dimethyl- 2- pyrrolidinecarboxamideIBA 01/2018 - 01/2008
2	Arginine Vasopressin (Argipressin)IBA 05/2017 - 02/2015
2	Analgesics (Analgesic Drugs)IBA 05/2017 - 07/2010
2	Proteins (Proteins, Gene)FDA Link 11/2015 - 06/2003
2	Biological ProductsIBA 06/2012 - 06/2002
2	Nicotine FDA Link 04/2009 - 03/2003
2	Corticotropin-Releasing HormoneIBA 04/2009 - 05/2003
2	Messenger RNA (mRNA)IBA 04/2009 - 01/2008
2	Capsaicin (Zostrix)FDA Link 10/2004 - 09/2003
1	Glutamate Receptors (Glutamate Receptor)IBA 03/2022
1	Anesthetics (Anesthetic Agents)IBA 09/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2021
1	Naloxone Drug Combination Buprenorphine FDA Link 11/2020
1	BenzodiazepinesIBA 11/2019
1	CRF receptor type 2IBA 01/2019
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	activity regulated cytoskeletal-associated proteinIBA 01/2019
1	Mitogen-Activated Protein KinasesIBA 01/2019
1	Neuropeptide YIBA 01/2019
1	Bupropion (Wellbutrin)FDA LinkGeneric 01/2019
1	Sucrose (Saccharose)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Medical MarijuanaIBA 01/2018
1	beta-Arrestin 1IBA 01/2018
1	N-benzoyl-N-phenylhydroxylamineIBA 01/2018
1	mesyl salvinorin BIBA 01/2018
1	Anti-Anxiety Agents (Anxiolytics)IBA 08/2017
1	Antidepressive Agents (Antidepressants)IBA 08/2017

Therapy/Procedure

5	Therapeutics 01/2022 - 02/2003
5	Drug Therapy (Chemotherapy) 01/2019 - 01/2002
3	Self Administration (Administration, Self) 11/2020 - 01/2008
3	Highly Active Antiretroviral Therapy (HAART) 03/2013 - 10/2011
2	Analgesia 01/2018 - 02/2011
1	Precision Medicine 01/2021